• Tuesday, August 16 - 14:00 hrs.

New Horizons in Material Research: Study of In vivo Biomaterials with Advanced Imaging Methods

A wide variety of imaging measures of biophysical properties of animal and human tissues in vivo offer unique opportunities to study complex physiological processes and biomaterial characteristics over spatial and temporal dimensions to provide information unobtainable by standard laboratory methods. The Colorado Translational Research Imaging Center C-TRIC uses a spectrum of devices including X-rays, CT, US, Doppler US, MRI, PET, PET/CTs and MR/PET to measure tissue properties in vivo. N-dimensional imaging studies over the coming decade promise new and fundamental knowledge of life processes of critical importance to the future of humanity and the planet on which we live.



Ph.D. Gary D. Fullerton

Dr. Fullerton’s primary research interests over the past decade have focused on the use of imaging to provide quantitative measures of imaging biomarkers that can be used for the evaluation and prediction of the course of disease processes. Initial focus was on Magnetic Resonance Imaging where he served as President of the Society of Magnetic Resonance Imaging (predecessor of the ISMRM) and founding Editor-in-Chief of the Journal of Magnetic Resonance Imaging. Research into the basis of MR relaxation effects (source of MRI contrast) led to discovery of the molecular basis of “magic angle” effect that is now becoming more used as a basis for diagnostic specificity in recent developments of MSK (musculoskeletal) imaging. In addition he has promoted increased application of physics principles in the study of biology, disease and the methods of medicine while serving as the President of the American Association of Physicists in Medicine and Secretary General of the International Organization of Medical Physics. Dr. Fullerton now uses a combination of NMR, microCT, Differential Scanning Calorimetry and gravimetric methods to evaluate the interaction of water with macromolecules but most especially with collagen and tendon. These studies are systematically evaluating the Stoichiometric Hydration Model to demonstrate that bound water consists of water bridges bound by hydrogen bonds in a repeating pattern to partial charge sites on the backbone of the protein molecule. It is this electrostatic binding of water that accounts for the magic angle effect used in orientational imaging as well as accounting for the basis of NMR relaxation effects. Presently he is exploring the influence of water bridges on the motion and behavior of water clusters hydrogen bonded directly to water bridges. He is also exploring the use of bovine tendon as a model to measure molecular diameters of co-solutes using a combination of microCT and the 107 amplification factor of semi-crystalline collagen. These studies have the potential of allowing direct study of protein response to water solvent and co-solute conditions imposed by pH, salt type, salt concentration as well as the influence of uncharged co-solutes such as glucose. It is expected that understanding of glucose interactions with the collagen molecule will lead to improved understanding of the influence of hyperglycemia and therapies to treat the long term symptoms of diabetes.

Awards/Honors

• Recipient of Undergraduate Scholarship, Student Engineering
• Development Program, Pacific Missile Range, Point Mugu, California
• Outstanding Radiology Resident Instructor Award, UTHSCSA
• President of the Society of Magnetic Resonance Imaging
• President of the World Congress on Medical Physics and Biomedical Engineering
• Fellow of the American Association of Physics in Medicine
• Fellow of the Society of Magnetic Resonance Imaging
• President of the American Association of Physicists in Medicine
• Founding Editor of the Journal of Magnetic Resonance Imaging
• Robert J. Shalek Award for Achievement in Medical Physics
• Named UTHSCSA Malcolm Jones Professor of Radiology
• Fellow of the American Institute of Medical and Biological Engineering
• Fellow of the International Society of Magnetic Resonance in Medicine
• Fellow of the American College of Radiology
• Trustees or the RSNA Research and Education Foundation
• Secretary General of the International Organization for Medical Physics
• Secretary General of the International Union of Physical and Engineering Sciences in Medicine
• Named UTHSCSA Malcolm Jones Distinguished Professor of Radiology
• Recipient of the IUPESM Silver Medal for Society Service (10 years as Founding Editor-in-Chief of the Journal of Magnetic Resonance Imaging)
• Member Board of Governors Academy of Radiology Research
• Recipient of the IUPESM Award of Merit for Outstanding Achievements in Physical and Engineering Sciences in Medicine






Ph.D. Gary D. Fullerton


Director Colorado Translational Research Imaging Center
Fellow ACR, AAPM, IOMP, ISMRM, AIMBE
Radiology Department
University of Colorado Denver





  
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XX INTERNATIONAL MATERIALS RESEARCH CONGRESS 2011
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