Duration: 5 h
The worldwide incidence of bone disorders has increased in last years and it is expected to remain raising in the future, particularly in aging populations. The surface of the material plays a crucial role for the success of long-term osseointegrated implants, such as hip, knee or dental implants. In fact, the surface of the material should be able to induce the formation of bone (for the fixation of the implant) while should minimize the possibility of colonization by microorganisms (to avoid infection). Also, the surface should minimize corrosion and mechanical wear as metallic biomaterials are preferentially used in those applications. This tutorial introduces materials of natural and synthetic origin and a brief survey of historic, current, and future applications of materials in medicine, with focus on nanotechnology approaches to functionalize surfaces. Classes and properties of degradable and non-degradable materials, interactions of materials with cells and tissues, and fundamentals of biocompatibility including inflammation, encapsulation, and infection will be addressed.
- State of art and clinical application of biomaterials
- Nanostructures and osseointegrated implants response
- Predict host response to various classes of biomaterials regarding biocompatibility, function, and failure
- Illustrate cell-biomaterial and tissue-biomaterial interactions